abstract |
REFERS TO AMIDE DERIVATIVES OF FORMULA I WHERE X IS O, SO2, R IS HETEROAROMATIC RING OF 5 TO 6 MEMBERS WITH 1-2 HETEROATOMS SELECTED FROM O, S, N ARYL, AMONG OTHERS; x E y SON 0-1; | R1 IS A C5-C6 CYCLOALKYL RING; R2 IS CO-NHR3 OR A 5 TO 6-MEMBER HETEROAROMATIC RING JOINED THROUGH A CARBON ATOM TO THE AMIDA GROUP SHOWN, WHOSE HETEROAROMATIC RING CONTAINS 1 TO 3 HETEROATOMS; R3 IS H, LOWER ALKYL, (CH2) p-CO-OR7; p IS 0-5; R7 IS H, RENT. 2-BIPHENYL-4-IL-3-CYCLOPENTIL-N-THIAZOL-2-IL-PROPIONAMIDE, (2R) -2-BIPHENYL-4-IL-3-CYCLOPENTIL-N-THIAZOL-2-IL-PROPIONAMIDE ARE PREFERRED COMPOUNDS , 3-CYCLOPENTIL-2- (4-NAPHTHALEN-1-IL-PHENYL) -N-THIAZOL-2-IL-PROPIONAMIDE, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION AND A PROCESS FOR THE PREPARATION. THE SUBSTITUTED PARA-ARIL OR HETEROARYL PHENYL AMIDES ARE GLUCOKINASE ACTIVATORS AND INCREASE INSULIN SECRETION AND ARE USEFUL FOR THE TREATMENT OF TYPE II DIABETES |