| abstract |
REFERS TO FORMAULA I BENZOTHIAZOLES COMPOUNDS WHERE R1 IS C3-C6 CYCLOALKYL, C1-C3 ALKYL; R2 IS C1-C6 ALKYL, C3-C6 CYCLOLAKYL, CF3, CH2CF3, C2F5, NR4R5; R3 IS PYRAZOLE FROM FORMULA (A), IMIDAZOLE, ISOXAZOLE WHERE R6 IS C1-C3 ALKYL; R7 IS H, C1-C3 ALKYL, HALOGEN, CF3, CN; NR4R5 IS A HETEROCICLO RING WITH N. ARE PREFERRED COMPOUNDS (3,5-DIMETHYLISOXAZOLE-4-IL) AMIDE OF THE ACID 2-ETHYL-4-METOXYBENZOTIAZOL-7-CARBOXILICO, (3,5-DIMETTILISOXAZOL-4-IL) 4-METHOXY-2- (MORPHOLIN-4-IL) BENZOTHIAZOLE-7-CARBOXYL ACID; (3,5-DIMETHYLISOXAZOLE-4-IL) 2-CYCLE-PROPYL-4-METOXYBENZOTHIAZOLE-7-CARBOXYL ACID AMIDE, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. THE COMPOUND OF FORMULA I INHIBITS IV PHOSPHODIESTERS (PDE4) AND / OR TUMOR NECROSIS FACTOR (TNF) USEFUL FOR THE TREATMENT OF INFLAMMATORY DISEASES, ASTHMA, BRONCHITIS, DERMATITIS, RHINITIS |