| abstract |
REFERS TO DIAMINE DERIVATIVES OF FORMULA I WHERE R1 IS H, ARYL, ARALKYL, HETEROCYCLYL, DIARYALKYL, HETEROCYCLYL-ALKYL, AMONG OTHERS; R2 IS ARYL, ARALKYL, CYCLOALKYL, CYCLOALKYL-ALKYL, HETEROCYCLYL, HETEROCYCLYL-ALKYL, AMONG OTHERS; X1, X2, X3, X4 ARE CO, SO2 PROVIDED THAT AT LEAST ONE BETWEEN X1 AND X2 AND AT LEAST ONE BETWEEN X3 AND X4 IS CO, SO2; A IS ALKYL, ALKENYL, CYCLOALKYL, CYCLOALKYL-ALKYL, ALKYL-CYCLOALKYL, CYCLOALKENYL, AMONG OTHERS; R3 IS H, ARYL, HETEROCYCLYL, ARALKYL, DIARYALKYL, HETEROCYCLE-ALKYL, AMONG OTHERS; Y IS -O-, -NH-, -S-, -SO2-; n IS 0-5; R4 IS H, AMINO, ALKYLAMINE, DIALKYLAMINE, N-ALKYL-N-ARALKYL-AMINO, AMONG OTHERS; R5 IS H, HALOGEN, NITRO, CYANE, AMINO, ALKYLAMINE, AMONG OTHERS. DIAMINE DERIVED COMPOUNDS ARE MOTILIN RECEPTOR ANTAGONISTS AND ARE USEFUL FOR THE TREATMENT OF GASTROINTESTINAL REFLUX DISORDERS, EATING DISORDERS LEADING TO OBESITY AND IRRITABLE COLON SYNDROME |