abstract |
REFERS TO OXAZOLIDINONE THIOAMIDES WITH PIPERAZIN-AMIDE SUBSTITUENTS OF FORMULA I WHERE A IS GROUP i, ii AMONG OTHERS; W IS NHC (= S) R1, -Y-het PROVIDED THAT A IS AN iv STRUCTURE, W IS NOT -Y-HET; Y IS NH, O, S; R1 IS H, NH2, NH-C1-C4 ALKYL, C1-C4 ALKYL, 0-C1-C4 ALKYL, AMONG OTHERS; R2 AND R3 ARE H, F, Cl, C1-C2 ALKYL; R4 IS -C (= O) -CR5R6-O-R7, -C (= O) -CH2S (O) n-CH3, AMONG OTHERS; R5 IS H; R6 IS PHENYL, BENZYL, CH2OH, CH2OCH3; R5 AND R6 ARE C3-C5 CYCLOALKYL; R7 IS H, CH3, C1-C4 ALKANOYL. PREFERRED COMPOUNDS ARE N {[5S) -3- (3-FLUORO-4-} 4- [2- (METHYLSULFINYL) ACETYL] -1-PIPERAZINYL} PHENYL) -2-OXO-1,3-OXAZOLIDIN-5-IL ] METHYL} PROPANTIOAMIDE, N {[5S) -3- (3-FLUORO-4-} 4- [2- (METHYLSULPHANIL) ACETYL] -1-PIPERAZINYL} PHENYL) -2-OXO-1,3-OXAZOLIDIN-5 -IL] METHYL} PROPANTIOAMIDE, AMONG OTHERS. FORMULA I COMPOUNDS HAVE ANTIBACTERIAL ACTIVITY |