| abstract |
REFERS TO THE USE OF HETERO CYCLIC DIHYDROPYRIMIDINE OF FORMULA I WHERE X1, X2, X3 ARE N, NR6, (CR7) q, (CHR7) q, C = O; R1-R7 ARE (CH2) n (Z1) m- (CH2) p-Z2 OR R1-R5 FORM CARBOCYCLE, HETEROCYCLE; R6 AND R7 ARE CARBOCYCLE, HETEROCYCLE; Z1 IS CZ3Z4, O, NZ3, S, SO, AMONG OTHERS; Z2 IS H, OZ5, OCOZ5, NZ5, AMONG OTHERS; Z3- Z7 ARE H, HALO, ALKYL, AMONG OTHERS; Z3- Z7 FORM ONE OR MORE PAIRS CARBOCICLO, HETEROCICLO; n and p ARE 0-10; m IS 0-1; q IS 1-3. A PREFERRED COMPOUND IS 7- (2,3-DICHLOROPHENYL) -4,7-DIHYDRO-5-METHYLPYRAZOLE [1,5-a] PYRIMIDIN-6-CARBOXYL ACID METHYL ESTER; AMONG OTHERS. IT ALSO REFERS TO A COMPOSITION THAT ALSO INCLUDES AN ANTIARRHYTHMIC AGENT (SOTALOL, DILTIAZEM, VERAPAMILO); CALCIUM CHANNEL BLOCKER, AN ANTI-PLATELET AGENT (CLOPIDOGREL, ASPIRIN); AN ANTIHYPERTENSIVE AGENT SUCH AS ß-ADRENERGIC BLOCKERS, ACE INHIBITORS (CAPTOPRIL), VASOPEPTIDASE INHIBITORS (OMATRILAT, GEMOPATRILAT), AN ANTITHROMBOTIC AGENT (FACTOR VIIA INHIBITOR, XA); ANTICOAGULANT (WARFARIN, HEPARIN); HMGCoA INHIBITOR (ATORVASTATIN); ANTIDIABETIC AGENT (BIGUANIDE); MINERALOCORTICOID RECEPTOR ANTAGONIST (SPIRONOLACTONE); CARDIAC GLYCOSIL (DIGITALIS, OUABAIN). THE COMPOUND IS AN INHIBITOR OF THE POTASSIUM CHANNEL AND MAY BE USEFUL FOR THE TREATMENT OF ARRHYTHMIAS OF FIBRILLATION, SUPRAVENTRICULAR ARRHYTHMIAS, GASTROINTESTINAL DISORDERS, INFLAMMATORY, IMMUNOLOGICAL, OBSTRUCTIVE CHRONIC DISEASES |