| abstract |
IT REFERS TO THE USE OF AN INHIBITOR ACIL COENZYME A: ACYLTRANSFERASE CHOLESTEROL (ACAT) TO REDUCE THE ACCUMULATION OF MONOCYTES-MACROPHAGES AND THE EXPRESSION OF METALOPROTEASES (MMP) IN THE ATTEROSCLEROTIC PLATES USEFUL IN TRESATTABLE ANGLE; SUCH AS A COMPOUND OF FORMULA I WHERE X, Y ARE O, S, (CR'R ") n; n IS 1-4; R 'YR" ARE H, C1-C6 ALKYL, C1-C6 ALCOXY, C3- CYCLOALKYL C10, CARBONYL, AMONG OTHERS; R IS H, C1-C8 ALKYL, BENZYL; R1 AND R2 ARE PHENYL, PHENOXY; NAFTILO, ARYLALKYL; ADAMANTILO. PREFERRED COMPOUNDS are [[2,4,6-TRIS (1-METHYLETHYL) PHENYL] ACETYL] -2,6-BIS (1-METHYLETHYL) PHENYL ESTER OF SULPHAMIC ACID; (+/-) 2-DODECIL-O-PHENYL-N- (2,4,6-TRIMETOXIFENIL) -2H-TETRAZOLE-5-ACETAMIDE; (+/-) N- [2,6-BIS (1-METHYLETHYL) PHENYL] -2- (2-DODECIL-2H-TETRAZOL-5-IL) -2-PHENYL-ACETAMIDE, AMONG OTHERS |