abstract |
REFERS TO BENZOXA OR BENZOTHIAZOLES SUBSTITUTED IN POSITION 2 AND WITH AN ESTER OF SULFAMIC ACID LINKED BY OXYGEN TO THE PHENYL OF THE COMPOUND OF FORMULA I; WHERE X IS O, S; R1 AND R2 ARE H, ALKYL; OR ONE IS H AND THE OTHER IS ACILO, ALCOXICARBONIL; R3 IS RENTAL, ALKENYL, ALKINYL, CYCLOALKYL, AMONG OTHERS. A PREFERRED COMPOUND IS SULPHAMIC ACID 2- (ADAMANTAN-2-ILIDENMETIL) BENZOXAZOL-6-IL-ESTER. IT ALSO REFERS TO A PROCEDURE FOR THE PREPARATION, TO INTERMEDIATE COMPOUNDS. COMPOUND I INHIBITS STEROID SULFATASE REDUCING ENDOGENOUS LEVELS OF ANDROGENS, ESTROGENS IN THE SKIN AND MAY BE USEFUL IN THE TREATMENT OF ACNE, SEBORRHEA, ANDROGENIC ALOPECIA, HIRSUTISM, SCALE CARCINOMAS |