| abstract |
REFERS TO NITRILE DERIVATIVES OF FORMULA I WHERE Y IS O, S, CH-R2; R1 AND R3 ARE H, METHYL; OR R2 AND R3 ARE CH2 TO FORM CYCLOPROPYL; R4 AND R5 ARE H, ALKYL; R6 IS CYCLOALKYL, ARYL, ARYL-ALKYL, HETEROARYL, HETEROARYLALKYL; R7 IS CORa, SO2Rb, CSNHRc; Ra IS ALKYL, CYCLOALKYL, ARYL, HETEROARYL, AMONG OTHERS; Rb IS ALKYL, CYCLOALKYL, ARYL, HETEROARYL; Rc IS RENT, CYCLOALKYL, ARYL, HETEROARYL. PREFERRED COMPOUNDS ARE (S) -2 - [(R) - (BENZO [1,3] DIOXOL-5-IL-CYAN-METHYL) -CARBAMOYL] -PYRROLIDIN-1-CARBOXYLIC ACID BENZYL ESTER; ACID (S) -1- [2- (3-BROMO-PHENYL) -ETHANOYL] -PYRROLIDIN-2-CARBOXYL (1-BENZO [1,3] DIOXOL-5-IL-1-CYAN-METHYL) -AMIDE, AMONG OTHERS. IT ALSO REFERS TO A PROCEDURE FOR PREPARATION. COMPOUND I IS AN INHBIDOR OF CYSTEIN PROTEASES AND MAY BE USEFUL FOR THE TREATMENT OF OSTEOPOROSIS, OSTEOARTHRITIS, RHEUMATOID ARTHRITIS, TUMOR METASTASIS, GLOMERULONEPHRITIS, ATHEROSCLEROSIS |