| abstract |
REFERS TO OXAZOLIDINONES OF FORMULA I, WHERE A IS i, iii, iv, AMONG OTHERS; B IS a, b, c; W IS NHC (= X) R1, Y-HET; WHEN A IS iv; W IS NOT Y-HET; X IS O, S; WHEN X IS O; B IS NOT b; Y IS NH, O, S; Z IS S (= O) (= NR5); R1 IS C1-C4 ALKYL, C3-C6 CYCLOALKYL (CH2) p OPTIONALLY SUBSTITUTED WITH F, Cl, CN; R2 AND R3 ARE H, F, Cl, ALKYL; R4 IS H, CH3, F; R5 IS C1-C5 ALKYL, C1-C4 CO-ALKYL, AMONG OTHERS; p IS 0-2; n IS 2-3; j ES 1-5; PREFERRED COMPOUNDS ARE N - ({(5S) -3- [3-FLUORO-4- (1-IMINO-1-OXIDO-1 4, THIAZINAN-4-IL) PHENYL] -2-OXO-1,3-OXAZOLIDIN -5-IL) METHYL) ETHANTHIOAMIDE, N - ({(5S) -3- [3-FLUORO-4- (1-IMINO-1-OXIDO-1 4,4-THIAZINAN-4-IL) PHENYL] -2 -OXO-1,3-OXAZOLIDIN-5-IL) METHYL) PROPANTHIOAMIDE, AMONG OTHERS. COMPOUND I MAY BE USEFUL AS AN ANTIBIOTIC IN EYE, CUTANEOUS INFECTIONS; USING FROM 0.1 mg / Kg OF WEIGHT / DAY TO 100 mg / Kg OF WEIGHT / DAY |