| abstract |
REFERS TO THE USE OF AN INHIBITOR OF THE SECRETION OF APOLIPOPROTEIN B / TRANSFER PROTEIN OF MICROSOMAL TRIGLYCERIDES TO REDUCE FOOD CONSUMPTION IN AN ANIMAL OF FORMULA I, WHERE L IS X-Y-Z; X IS CH2, CO, CS, SO2; AND IT IS A LINK, C1-C20 ALIPHATIC HYDROCARBYLENE REPLACED BY OH, C1-C10 ALCOXYL, C1-C10 ACYL, C1-C10 ACYLOXYL, C6-C10 ARYL, NH, O; WHEN X IS CH2, Y IS A LINK; Z IS H, HALOGEN, CYANE, OH, C1-C10 ALCOXYL, C1-C10 ALKYLTIO, C1-C10 ALKYLAMINE, VINYL, C6-C10 ARYLOXYL, HETEROCICLYL; WHEN Z CONTAINS ONE OR MORE RINGS OPTIONALLY SUBSTITUTED WITH HALO, OH, CYANE, AMONG OTHERS; G IS PHENYL, HETEROCYCLE, CH2CN, GROUP a, AMONG OTHERS; R3 IS NR1R2, PHENYL, C1-C10 ALKYL, C1-C4 PERFLUOROALKYL, AMONG OTHERS. PREFERRED COMPOUNDS ARE (2-BUTYL-1,2,3,4-TETRAHYDROISOQUINOLIN-6-IL) -AMIDE OF THE 4'-TRIFLUOROMETHYL-BIPHENYL-2-CARBOXYL ACID; [2- (2-ACETYLAMINOETHYL) -1,2,3,4-TETRAHYDROISOQUINILIN-6-IL] -AMIDE OF 4'-TRIFLUOROMETHYL-BIPHENYL-2-CARBOXYL ACID, AMONG OTHERS. ALSO REFERS TO USE WITH AN ANTI-OBESITY AGENT SUCH AS SIBUTRAMINE, ORLISTAT, FENFLURAMINE, DEXFENFLURAMINE, BROMOCRYPTINE, PHENTERMINE, EPHEDRINE, LEPTHINE, PENYLPROPANOLAMINE, PSEUDOEPHEDRINE, BETWEEN OTHERS |