| abstract |
IT REFERS TO AN ORAL LIQUID COMPOSITION THAT HAS IMPROVED STABILITY, INCLUDING a) AN ACTIVE AGENT OF MOLECULAR WEIGHT LESS THAN 500 g / MOL, AS ANTITUSSIVES, ANTIHISTAMINES, DECONGESTANTS, EXPECTORANTS, ANTI-AGENTS, ANTI-CHOLYTICS; b) A HYDROPHYL ANHYDRO SOLVENT, MISCIBLE IN WATER SUCH AS PROPYLENE GLYCOL, ETHANOL, PROPYLENE CARBONATE, AMONG OTHERS; c) FROM 0.005% TO 1% OF A CHELATING AGENT SUCH AS DISODIC SALTS, ETHYLENDIAMINOACETIC ACID CALCICES, TETRASODIUM EDTA, CITRIC ACID, AMONG OTHERS, WHICH IS IN A DIFFERENT PHASE FROM THE ACTIVE PHASE, WHICH HAS IMPROVED STABILITY; d) FROM 0.0050% TO 1% OF A REDUCING AGENT SUCH AS BISULPHITE, SODIUM, POTASSIUM SALTS, DITIOERITHRIOL, THIOUREA, AMONG OTHERS WITH A POTENTIAL OF ELECTRODE E ° GREATER THAN -0.119V, THE CHELATING AND REDUCING AGENT ARE ACTIVE AT A pH OF 5 TO 12, IN AQUEOUS AND NON-AQUEOUS SOLVENT COMPOSITIONS; THE ACTIVE AGENT IN ITS NON-IONIZED FORM HAS A SOLUBILITY AT AMBIENT TEMPERATURE EQUAL TO OR GREATER THAN 0.75%; THE ACTIVE AGENT IS CAPABLE OF BEING IONIZED IN AQUEOUS SOLVENT, IT HAS A PARTITION COEFFICIENT OF OCTANOL: WATER WHEN IT IS IN THE NON-IONIZED FORM OF 100. THE COMPOSITION MAY BE USEFUL TO TREAT RESPIRATORY DISEASES USING NO MORE THAN 3ml |