| abstract |
REFERS TO HYDROXAMIC ACID COMPOUNDS OF FORMULA I, WHERE: X IS OH, NHOH; R1 IS GROUP a, b, AMONG OTHERS; Y IS O, S, S (O) d, CH2, AMONG OTHERS; d IS 1-2; R2 IS H, C1-C4 ALKYL, BENZYL OPTIONALLY SUBSTITUTED WITH C1-C4 ALKYL, C1-C4 ALCOXY, F, Cl, Br, I, NH2, NO2, CN, CARBOXI, CO2R7; R7 IS H, C1-C4 ALKYL; R3 AND R4 ARE C1-C20 ALKYL, C3-C10 CYCLOALKYL, PHENYL OPTIONALLY SUBSTITUTED WITH C1-C4 ALKYL, C1-C4 ALCOXY, HALO, NH2, NO2, CN, COOH, CO2R7, CF3, C3-C19 HETEROCYCLIC, BETWEEN C3-C19. PREFERRED COMPOUNDS ARE 1- (4`-BROMO-BIPHENYL-4-SULFONYLAMINE) -CYCLOPENTAN0-CARBOXYL ACID; 1- (4'-BROMO-BIPHENYL-4-SULFONYLAMINE) -CYCLOPENTANE-CARBOXYL ACID HYDROXAMIDE, 2-METHYL-2- (6,7,8,9-TETRAHYDRO-DIBENZOFURAN-3-SULFONYLAMINE) PROPIONIC ACID, BETWEEN OTHERS . THE HYDROXAMIC ACID COMPOUNDS OF FORMULA I ARE INHIBITORS OF THE MATRIX METALOPROTEINASE SO THEY MAY BE USEFUL IN THE TREATMENT OF ARTHRITIS, MULTIPLE SCLEROSIS, ATHEREOESCLEROSIS, RESTENOSIS, OSTEOPROTEINASE, INFLUENZA, ANTHEOPOROSIS |