abstract |
IT REFERS TO A PROCEDURE TO PREPARE FORMULA I SUBSTITUTED 4-CYANOCYCLOHEXANOCARBOXYLATES, WHERE: R IS HALO, C1-C6 ALKYL, C1-C6 ALCOXY, C1-C6 ALKENYL, -O- (CH2) m-CYCLE-ALKYL n IS 1-5; m IS 0-6; R` Y R2 ARE H, CO (O) X; X IS H, C1-C6 ALKYL; WHICH INCLUDES DECARBOXYLATE THE DIACIDE OR DIESTER OF FORMULA A, WHERE R1 IS H, C1-C6 ALKYL ESTER; COMBINING WITH AN EQUIVALENT OF A BASE, 3 EQUIVALENTS OF WATER, 3 EQUIVALENTS OF AN ALKALINE SALT IN A SOLVENT; HEATS FROM 100 ° C TO 150 ° C FOR 4-8 HOURS. IT ALSO REFERS TO INTERMEDIARY COMPOUNDS AND PROCEDURES TO OBTAIN THESE COMPOUNDS. COMPOUNDS I ARE INHIBITORS OF PHOSPHODIESTERASE 4 |