| abstract |
REFERS TO DERIVATIVES OF 1-TRIFLUORomethyl-4-HYDROXY-7-PIPERIDINYL-AMINOMETILCROMANO OF FORMULA I, WHERE: R1 IS A C1-C6 ALKYL, R2 IS H, C1-C6 ALKYL, C1-C6 HALKYL, PHENYL; R3 IS H, HALO; R4 AND R5 ARE H, C1-C6 ALKYL, C1-C6 HALOALKYL. A PREFERRED COMPOUND IS (2S, 3S) -3- (6-METHOXY-4-HYDROXY-1-METHYL-1-TRIFLUOROMETHYLISOCROMAN-7-IL) METHYLAMINE-2-PHENYL] PIPERIDINE. THE DERIVATIVES OF 1-TRIFLUROMETHYL-4-HYDROXY-7-PIPERIDINYL-AMINOMETILCROMANO ARE ANTAGONISTS OF NEUROPEPTIDES, SUBSTANCE P SO IT MAY BE USEFUL FOR THE TREATMENT OF SEVERE DEPRESSIVE DISORDER, OBSESSIVE DEPRESSION-OBSERVIOUS TRADIASTORAL DISORDER PANIC, PHOBIAS, POST-TRAUMATIC STRESS DISORDER, PERSONALITY DISORDER |