abstract |
REFERS TO INDOLE DERIVATIVES OF FORMULA I AND II, WHERE: R IS HALOGEN, C1-C4 ALKYL, C1-C4 ALCOXY, NR`R ", NITRO, ARYL, C1-C4 ALKYLARYL, C1-C4 ALCOXY ARYL; R 'YR "ARE H, C1-C4 ALKYL, ClCH2CH2 OR NR'R" FORM A HETEROCICLIC RING WITH 3-8 MEMBERS; m IS 0-4; R1 IS H, C1-C4 ALKYL, C1-C4 ALKANOYL, C1-C4 ALKYLARYL, AMONG OTHERS: R2 IS H, HALOGEN, C1-C4 ALKYL, C1-C4 ALCOXY, ARYL, C1-C4 ALKYLARYL, ALCOXY ARYL-C1-C4, NR'R "; A IS C1-C4 ALKYLENE; X IS CH2, C = O, C = S; Y IS 2-FURILO, 2-DIHIDROFURILO, 2-TETRAHIDROFURILO, (2-R ° -COO-) PHENYL, SUBSTITUTED WITH C1-C4 ALKYL, C1-C4 ALCOXY, OH, NR'R "OY IS STIRILE WITH UP TO TWO RINGS ; R ° IS C1-C4 ALKYL, NR'R "; Z IS 2- (p- (3,5-DIOXOISOXAZOLIDIN-4-ILMETHYL) PHENOXY) ETHYLAMINE, p- (3,5-DIOXOISOXAZOLIDIN-4-ILMETHYL) PHENOXY, 2- (p- (2,4-DIOXOTIAZOLIDIN-5 -YLMETHYL) PHENOXY) ETHYLAMINE, AMONG OTHERS. PREFERRED COMPOUNDS ARE 5-METHOXY- (3- (2- (2-FURAMIDE) ETHYL) INDOLE; 5-METHOXY-3- (2- (TETRAHYDRO-2-FURAMIDE) ETHYL) INDOL, AMONG OTHERS. IT ALSO REFERS TO ONE PHARMACEUTICAL FORMULATION THAT INCLUDES 0.0025mg-1000mg OF COMPOUND IO II. THE DERIVATIVES OF INDOL ARE STRUCTURALLY AND FUNCTIONALLY RELATED TO MELATONIN; THEY HAVE ANTIOXIDANT, DEPURATORY ACTIVITY AND MAY BE USEFUL AS TOPIC SKIN PROTECTORS AND COSMETICS |