abstract |
REFERS TO DERIVATIVES OF 1,2,3,4,5,6-HEXAHIDROAZEPIN- [4,5-b] INDOLE THAT HAVE A RING TO JOIN POSITION 6 AND 7 OF FORMULA I WHERE R1 IS OH, NITRO, HALOGEN, CN, TRIFLUOROMETHYL, S (O) mNRaRb, NRcRd, S (O) mRe, AMONG OTHERS; R2 IS H, C1-C7 ALKYL, C1-C7 ALKANOYL, C1-C7 ALCOXYCARBONYL, AMONG OTHERS; X AND Y TOGETHER ARE A CHAIN WITH C ATOMS OPTIONALLY CONTAINING A GROUP -O-, -S-, -SO-, -SO2-, NRf OPTIONALLY SUBSTITUTED WITH OXO, OH, C1-C7 ALCOXYL; m IS 0-2; n IS 0-3; EACH Ra AND Rb ARE H, C1-C7 ALKYL, ARYL, C1-C7 ARYLALKYL, HETEROARYL, C1-C7 HETEROARYL ALKYL; Ra AND Rb TOGETHER WITH N FORM PYRROLIDINE, PIPERIDINE, MORFOLINO, THIOMORFOLINO; EACH Rc AND Rd ARE H, C1-C7 ALKYL, C1-C7 ALKANOYL, C1-C7 ALCOXYCARBONYL, ARYL, OR TOGETHER WITH N FORMING PYRROLIDINE, PIPERIDINE, MORPHOLINE, THYOMORPHOLIN, AMONG OTHERS; Re IS H, C1-C7 ALKYL, ARYL, AMONG OTHERS; Rf IS H, C1-C7 ALKYL, ARYL, C1-C7 ARYLALKYL, AMONG OTHERS; WITH THE CONDITION THAT AND IS NOT OXY, TIO, SULFINIL, NRf, AMONG OTHERS. PREFERRED COMPOUNDS ARE 5,6,9,10,11,12-HEXAHYDRO-4H, 8H-AZEPIN [4`, 5 ': 4.5] PYRROL [3,2,1-ij] QUINOLINE, 2-METHYL-5 , 6,9,10,11,12-HEXAHYDRO-4H, 8H-AZEPIN [4 ', 5': 4.5] PYRROL [3,2,1-ij] -QUINOLINE, AMONG OTHERS. COMPOUNDS I ARE BINDERS OF SEROTONIN 5-HT AND MAY BE USEFUL FOR THE TREATMENT OF DISEASES OF THE CENTRAL NERVOUS SYSTEM, DREAM, DEPRESSION |