| abstract |
REFERS TO A POLYMORPHIC FORM OF THE SALT OF MALEIC ACID OF 5- [4- [2- (N-METHYL-N- (2-PYRIDYL) AMINO) ETHOXY] BENZYL] -THAZOLIDINE-2,4-DIONA, IN FORM ISOLATED, PURE, CRYSTALINE CHARACTERIZED BY THE INFRARED SPECTRUM, RAMAN SPECTRUM, NUCLEAR MAGNETIC RESONANCE SPECTRUM IN SOLID STATE, X-RAY DIFRACTION PATTERN. IT ALSO REFERS TO A PROCEDURE FOR THE PREPARATION OF THE MILK CHARACTERIZED BY: a) SUSPENDED MILK. SALT OF MALEIC ACID OF 5- [4- [2- (N-METHYL-N- (2-PYRIDYL) AMINO) ETOXY] BENZYL] -TIAZOLIDINE-2,4-DIONA IN AQUEOUS ETHANOL CONTAINING UP TO ABOUT 2.5% P / V OF WATER, DURING A LONG PERIOD OF TIME, THEN THE DENATURALIZED ETHANOL POLYMORPH IS RECOVERED; b) THE COMPOUND IS MIXED WITH DENATURALIZED ETHANOL AND HEATED AT A HIGH TEMPERATURE FOR A LONG PERIOD OF TIME THEN THE POLYMORPH IS RECOVERED FROM THE SOLVENT; c) THE COMPOUND IS PLANTED IN DENATURAL ETHANOL CONTAINING UP TO 2.5% W / V WATER, AT 55 ° C WITH THE POLYMORPH, COOLED FROM 20 ° C TO 25 ° C. THE SALT COMPOUND OF MALEIC ACID IS USEFUL IN THE TREATMENT OF DIABETES MELLITUS |