abstract |
IT REFERS TO A PROCEDURE FOR THE PREPARATION OF DIAZINE COMPOUNDS OF FORMULA 1; WHERE R1 AND R2 ARE C1-C10 ALKYL, C1-C10 ALCOXY OPTIONALLY SUBSTITUTED WITH OH, C1-C6 ALCOXY; R15 IS H, C1-C10 ALKYL, (CH2) q (C6-C10 ARYL); q IS 0-4; G IS C (OH) R3R4, SiR3R4R5; R3, R4 AND R5 ARE C1-C6 ALKYL; WHICH INCLUDES TREATING A COMPOUND OF FORMULA 2 WITH a) AN ALKALINE METAL HYDROXIDE, ALKALINE EARTH IN A SOLVENT SUCH AS BUTAN-2-OL, ISOPROPANOL; WHEN G IS C (OH) R3R4; b) A FLUORIDE COMPOUND OF TETRA (C1-C6 ALKYL) AMMONIUM IN AN APROTICAL SOLVENT SUCH AS TETRAHYDROFURAN, DIETHYL ETHER, DIMETOXYETHANE, TOLUENE, DICHLOROMETHANE, AMONG OTHERS; WHEN G IS -SiR3R4R5. IT ALSO REFERS TO A PROCEDURE FOR THE PREPARATION OF INTERMEDIATE COMPOUNDS. THE COMPOUNDS OF FORMULA I MAY BE USEFUL FOR THE TREATMENT OF HYPERPROLIFERATIVE DISORDERS, CANCER |