| abstract |
REFERS TO A COMPOUND OF FORMULA I WHERE X IS OH, NHOH; W IS S, O, N (R33), (R33) C = C (R33`), N = C (R33), N = N; R33 AND R33 'ARE H, ALKYL, ALKENYL, ALKINYL, AMONG OTHERS; R1 IS CR6R6 R34 WHERE IS 0-4; R6 AND R6 'ARE H, ALKYL, ALKENYL, AMONG OTHERS; R34 IS H, OH, ALCOXY, ALKYL, AMONG OTHERS; R2 IS - (CR7R7 ') m-R35 WHERE m IS 0-4; R7 AND R7 'ARE H, ALKYL, ALKENYL, ALKINYL, AMONG OTHERS; R35 IS H, ALKYL, ALKENYL, AMONG OTHERS; R3 IS (CR8R8 ') n-R9; n IS 0-4; R8 AND R8 'ARE H, ALKYL, ALKENYL, ALKINYL, ARYL, AMONG OTHERS; R4 IS (CR10R10 ') z-A' - (CR10''R10 '' ') o-R11, A' IS O, S, SO2; z Y or SON 0-4; R10, R10 ', R10' ', R10' '' ARE H, ALKYL, ALKENYL, AMONG OTHERS; R11 IS H, ALKYL, ALKENYL, AMONG OTHERS; R5 AND R5 'ARE H, ALKYL, ALKENYL, ALKINYL, AMONG OTHERS; k IS 0-4; A ES (R12) C = C (R12 '), CC; R12 AND R12 'ARE H, ALKYL, ALKENYL, AMONG OTHERS; G IS H, (CR14R14 ') p-R15, AMONG OTHERS; p ES 0-4; R14 AND R14 'ARE H, ALKYL, ALKENYL, AMONG OTHERS; Z IS CYCLOALKYL, HETERO CYCLOALKYL, AMONG OTHERS. A PREFERRED COMPOUND IS 2 - {[4'-FLUORO- (1,1'-BIPHENYL) -4-IL] -SULFONYL} -AMINO-5-PHENYLPEN-4-TINOIC ACID, AMONG OTHERS. COMPOUND I IS AN INHIBITOR OF METALOPROTEASES SO IT MAY BE USEFUL IN THE TREATMENT OF RHEUMATOID ARTHRITIS, CANCER, CARDIOVASCULAR, CUTANEOUS, EYE DISORDERS |