http://rdf.ncbi.nlm.nih.gov/pubchem/patent/PE-20001520-A1
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c76ecadad74a1a35270b3e3a34d60f37 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-416 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-416 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-415 |
filingDate | 1999-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_71af454d807c01151118c681e6ade4d8 |
publicationDate | 2001-01-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | PE-20001520-A1 |
titleOfInvention | PHARMACEUTICAL COMPOSITIONS INCLUDING SUBSTITUTE DERIVATIVES OF INDAZOLE AS INHIBITORS OF PDE TYPE IV AND THE PRODUCTION OF TNF |
abstract | REFERS TO A PHARMACEUTICAL COMPOSITION THAT INCLUDES: a) AN INDAZOLE COMPOUND THAT INHIBITES TYPE IV PHOSPHODIESTERASE AND THE PRODUCTION OF TUMOR NECROSIS FACTOR OF FORMULA I WHERE: R IS H, C1-C6 ALKYL, (Z`) b (Z` ") c (C6-C10 ARYL), AMONG OTHERS; b AND c ARE 0-1; Z 'IS C1-C6 ALKYLENE, C2-C6 ALKENYLENE, Z' 'IS O, S, SO2, NR9; R1 IS H, C1-C7 ALKYL, C2-C3 ALKYL, PHENYL, AMONG OTHERS; R2 IS THE GROUP Ia, Ib, AMONG OTHERS; m IS 0-4; R3 IS H, HALO, CYANE, C1-C4 ALKYL OPTIONALLY SUBSTITUTED WITH HALO, CH2NHC (O) C (O) NH2, CYCLOPROPYL OPTIONALLY SUBSTITUTED BY R11, R17, NR9R10, C (O) NR9R10, AMONG OTHERS; R4 IS H, C (Y) R14, C (Y) NR17R14, CN, AMONG OTHERS; R5 IS R9, OR9, CH2OR9, CYANE, C (O) R9, CO2R9, AMONG OTHERS; R4 AND R5 TOGETHER FORM = O, R8; OR R5 IS H; R4 IS OR14, SR14, S (O) nR15, AMONG OTHERS; R6 IS METHYL, ETHYL; R7 IS OR14, SR14, SO2NR17R14, AMONG OTHERS; R8 IS = NR15, = NCR9R10 (C2-C6 ALKENYL), = NOR14, AMONG OTHERS; R9 AND R10 ARE H, C1-C4 ALKYL; R11 IS FLUORINE, R10; R12 IS C1-C6 ALKYL, C2-C3 ALKYL, AMONG OTHERS; R14 IS H, R15; R14 AND 17 TOGETHER WITH N FORM A RING OF 5 TO 7 MEMBERS; R17 IS OR9, R10. A PREFERRED COMPOUND I IS 1 (1-CYCLOPENTIL-3-ETHYL) -1H-INDAZOL-6-IL) -4-OXO-CYCLOHEXANOCARBONITRILE, AMONG OTHERS. THE COMPOSITION MAY BE USEFUL FOR THE TREATMENT OF CONGESTIVE HEART FAILURE (CHF) |
priorityDate | 1998-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 31.