abstract |
REFERS TO AROMATIC HETEROCYCLE COMPOUNDS OF FORMULA I, WHERE: Ar1 IS A HETEROCYCLE SUCH AS PYRROL, PYRROLIDINE, PIRAZOLE, IMIDAZOLE, AMONG OTHERS; Ar2 IS PHENYL, NAPHTHYL, QUINOLINE, ISOQUINOLINE, TETRAHYDRONAPHTHYL, AMONG OTHERS; L IS A C1-C10 CARBONED CHAIN, ONE OR MORE METHYLENE GROUPS ARE OPTIONALLY REPLACED WITH O, N, S, OPTIONALLY REPLACED WITH 0-2 OXO GROUPS, C1-C4 ALKYL; Q IS PHENYL, NAPHTHYLL, PYRIDINE, TETRAHYDROPYRANE, TETRAHYDROFURANE, C1-C6 ALCOXY, AMONG GOLD; R1 IS C3-C10 ALKYL, C3-C7 CYCLOALKYL, C3-C10 ALKENYL, C5-C7 CYCLOALKENYL, CYANE, METOXYCARBONIL; R2 IS C1-C6 ALKYL; R3 IS PHENYL, NAPHTHYLL, CONDENSED ARYL, CYCLOALKYL, C5-C7 CYCLOALKENYL, AMONG OTHERS; OR R1 AND R2 TOGETHER FORM A CONDENSED PHENYL OR PYRIDYL RING, R8 AND R13 ARE H, C1-C4 ALKYL; R4, R5, R6, R7, R9, R10, R11, R12 ARE MORPHOLINE, PIPERIDINE, PIPERAZINE, AMONG OTHERS; m, r, t ARE 0-2; X IS O, S. A PREFERRED COMPOUND IS 1- [5-TERC-BUTYL-2-p-TOLIL-2H-PYRAZOLE-3-IL] -3- [4- (2-MORFOLIN-4-IL-ETOXY) NAFTALEN-1-IL] UREA, AMONG OTHERS. A PROCEDURE FOR PREPARATION. COMPOUND I MAY BE USEFUL FOR THE TREATMENT OF AN INFLAMMATORY DISEASE SUCH AS RHEUMATOID ARTHRITIS, MULTIPLE SCLEROSIS, AUTOIMMUNE DISEASE |