abstract |
REFERS TO COMPOUNDS DERIVED FROM PYRAZOLOPYRIDINE OF FORMULA I, WHERE: R0 AND R1 ARE H, HALOGEN, C1-C6 ALKYL, C1-C6 ALCOXY OPTIONALLY SUBSTITUTED BY F; R2 IS H, C1-C6 ALKYL OPTIONALLY SUBSTITUTED BY F, AMONG OTHERS; R3 IS C1-C6 ALKYL, NH2; PREFERRED COMPOUNDS ARE 4- [2- (3-FLUORO-PHENYL) -6-TRIFLUOROMETHYL-PYRAZOLE [1,5-a] PYRIDIN-3-IL] -BENZENOSULFONAMIDE, 2- (3-FLUORO-PHENYL) -3- ( 4-METHANOSULFONYL-PHENYL) -6-TRIFLUOROMETHYL-PYRAZOLO [1,5-a] -PYRIDINE; 4- [2- (4-ETOXY-PHENYL) -6-TRIFLUOROMETIL-PIRAZOLO [1,5-a] PYRIDIN-3-IL] -BENZENOSULFONAMIDE, AMONG OTHERS. IT ALSO REFERS TO A PROCEDURE FOR PREPARATION. COMPOUND I IS A SELECTIVE COX-2 INHIBITOR; SO IT MAY BE USEFUL FOR THE TREATMENT OF PAIN, FEVER, INFLAMMATION |