abstract |
IT REFERS TO A PROCESS TO PREPARE A TRICYCLE COMPOUND OF FORMULA I, WHERE: R, R1, R2, R3 AND R4 ARE H, Br, Cl, F, ALKYL, ALCOXY; WHICH INCLUDES A) REACTING A COMPOUND II, WHERE RA, RB, RC, RD AND RE ARE H, HALO, ALKYL, ALCOXI; R5 IS ARYL, HETEROARYL; WITH A DEHYDRATOR TO PRODUCE AN IMINE OF FORMULA III; THE REACTION MIXTURE IS CONTACTED WITH AN ADDITIONAL AGENT; B) HYDROLIZE THE IMINE TO PRODUCE COMPOUND I; THE DEHYDRATOR CAN BE P2O5, P2O3, P2O3Cl4, POCl3, PCl3, PCl5, C6H6P (O) Cl2, PBr3, PBr5, SOCl2, SOBr2, COCl2 AND H2SO4; THE ADDITIONAL AGENT MAY BE AlCl3, FeCl3, ZnCl2, AlBr3, ZnBr2, TiCl4, SnCl4, CF3SO3H, HFSO3, HF / BF3, AMONG OTHERS. ALSO REFERS TO INTERMEDIATE COMPOUNDS AND THE IMINE OF FORMULA III. COMPOUND I MAY BE USED AS AN INTERMEDIARY TO PREPARE ANTIHISTAMINE COMPOUNDS OR INHIBITORS OF FARNESIL TRANSFERASE |