abstract |
REFERS TO PENYLETHYLAMINE DERIVATIVES OF FORMULA I, WHERE R IS H or F; IT ALSO REFERS TO A PROCEDURE FOR THE PREPARATION THAT INCLUDES: a) REACTING A COMPOUND OF FORMULA (2) WITH AN ETHYLAMINE DERIVATIVE OF FORMULA (3); WHERE PG1 IS A PROTECTIVE GROUP OF PHENOL, H; PG IS A PROTECTIVE GROUP FOR AMINA; n IS 0-1; m IS 1-2; AND IT IS FLUORINE, CHLORINE, BROMINE, IODINE, C1-C4 ALKYL, ARYLSULPHONATE; IN THE PRESENCE OF A HYDROXIDE OR CARBONATE BASE, C1-C4 ALKALINE ALCOHOLATES OR EARTH ALKALINE; IN INERT SOLVENTS SUCH AS DIMETHYLFORMAMIDE, ACETONITRILE, ETHYL ESTER OF ACETIC ACID, ETHYL ESTER OF FORMIC ACID, TOLUENE, C1-C4 ALCOHOL, b) SEPARATE THE PROTECTIVE GROUPS AND c) ISOLATE THE PRODUCT FROM THE REACTION. COMPOUND I IS AN ANTAGONIST OF LEUKOTRIENE LTB4 SO IT MAY BE USEFUL FOR THE TREATMENT OF ARTHRITIS, ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ULCEROUS COLITIS, GASTROPATIAS, ENTEROPATHIES, INDUCED BY CHEMISTRY, ALTHOX, NON-CUSTOMIZED AGENTS INJURIES |