abstract |
REFERS TO DIHYDROPYRIMIDINES OF FORMULA I, WHERE; R1 IS PHENYL, FURYL, TIENYL, TRIAZOLYL, PYRIDYL, C3-C6 CYCLOALKYL, GROUP a, b, c OPTIONALLY SUBSTITUTED WITH HALOGEN, TRIFLUOROMETHYL, NITRO, CYANE, TRIFLUOROMETHYL, CFR2 -8R10, N-R6-N-R6, CO-R3-N-R6 , -A-CH2-R11, AMONG OTHERS; R6 IS PHENYL OPTIONALLY SUBSTITUTED WITH HALOGEN; R7, R8, R9, R10 ARE H, PHENYL OPTIONALLY SUBSTITUTED WITH HYDROXY, C1-C6 ACIL, C1-C6 ALKYL; A IS O, S, SO, SO2; R11 IS PHENYL OPTIONALLY SUBSTITUTED WITH HALOGEN, NITRO, TRIFLUOROMETHYL, C1-C6 ALKYL, C1-C6 ALCOXY; R2 IS -XR12, -NR13R14; X IS A LINK, O; R12 IS H, C1-C6 ALCOXY (CARBONYL), A C1-C8 HYDROCARBON REST; R13 AND R14 ARE H, C1-C6 ALKYL, C3-C6 CYCLOALKYL; R3 IS H, AMINO, (H3CO) 2-C, FORMYL, CYANE, TRIFLUOROMETHYL, PYRIDYL, A HYDROCARBON REST; OR R3 IS OPTIONALLY SUBSTITUTED PHENYL WITH METHOXY; R2 AND R3 TOGETHER FORM -O-CH2-; R4 IS H, C1-C4 ALKYL, C2-C4 ALKENYL, BENZOYL, C2-C6 ACYL; R5 IS PYRIDYL OPTIONALLY SUBSTITUTED WITH HALOGEN, HYDROXY, CYANE, TRIFLUOROMETHYL, AMONG OTHERS. A PREFERRED COMPOUND OF FORMULA II. IT ALSO REFERS TO A PROCEDURE FOR PREPARATION. COMPOUND I HAS ANTIVIRAL ACTIVITY SO IT MAY BE USEFUL FOR THE TREATMENT AND PROPHYLAXIS OF ACUTE OR CHRONIC VIRIC DISEASES SUCH AS HEPATITIS B |