| abstract |
REFERS TO A COMPOUND OF FORMULA I, WHERE R1 IS OH, ALCOXY, NR3OR3; R3 IS H, ALKYL, ACILO; X IS SO2, CO, CO2, CONR5, POR5, LINK; R5 IS H, ALKYL, HETEROALKYL, ARYL, HETEROARYL, CYCLOALKYL, HETEROCYCLOALKYL, Aryloxy, Heteroaryloxy; R2 IS H, ALKYL, HETEROALKYL, ARYL, HETEROARYL, CYCLOALKYL, HETEROCYCLOALKYL, Aryloxy, HETEROaryloxy; Z IS 1) N-W; n IS 1; W IS ARYL, HETEROARIL, CYCLOALKYL, HETEROCYCLOALKYL; 2) N-OR4, N-NR4, N-SR4R4, N-CR4R4R4; n IS 1; R4 IS H, ALKYL, HETEROALKYL, ARYL, HETEROARYL, CYCLOALKYL, HETEROCYCLOALKYL; 3) CR6R6; R6 IS H, HALO, ALKYL, HETEROALKYL, ARYL, HETEROARYL, CYCLOALKYL, HETEROCYCLOALKYL, CYANE; 4) CYCLOALKYL, HETEROCYCLOALKYL; 5) C = CR4R4; 6) C = V; V IS CYCLOALKYL, HETEROCYCLOALKYL; m AND n ARE 0-4; m + n = 2-7. COMPOUND I IS AN INHIBITOR OF METALOPROTEASES AND MAY BE USEFUL FOR THE TREATMENT OF ARTHRITIS (OSTEOARTHRITIS, RHEUMATOID ARTHRITIS), CANCER (PREVENTS OR COUNTERS THE GROWTH OF A TUMOR AND METASTASIS), CARDIACDIYAL DISEASE PROBLEM, , PLATE RUPTURE), SKIN PROBLEMS, EYE PROBLEMS (CORNEA ULCERATION, LACK OF CORNEA HEALING, MACULAR DEGENERATION), DISEASES OR INFLAMMATION OF THE GUM (PERIODONTAL DISEASE, GINGIVITIS) |