abstract |
REFERS TO CHROMANONE AND THIOCHROMANONE DERIVATIVES OF FORMULA I, WHERE R1 AND R2 ARE H, ACILO, ALCOXICARBONIL, ALKYL, THE SULFAMOYLOXI CHAIN IS LINKED IN POSITION 6 or 7; R3 IS ALKYL, ALKENYL, ALKINYL, A FRACTION OF CYCLOALKYL SUBSTITUTED BY ALKYL, ALCOXY, HALOGEN, AMONG OTHERS; R4 IS H, ALKYL, HYDROXY, ALCOXY; X IS O, S. ARE PREFERRED COMPOUNDS 2-BUTYLOTHERTIARY-4H-CHROMEN-4-ONA-6-O-SULFAMATE; 2- (1-ADAMANTIL) -4H-CHROMEN-4-ONA-6-O-SULFAMATE, 2- (1-ADAMANTIL) -4H-THIOCHROMEN-4-ONA-6-O-SULFAMATE. IT ALSO REFERS TO A PROCEDURE FOR PREPARATION. COMPOUND I IS AN INHIBITOR OF STEROID SULFATASE REDUCING ENDOGENOUS LEVELS OF ANDROGEN AND / OR ESTROGEN IN THE SKIN AND MAY BE USEFUL FOR THE TREATMENT OF ANDROGEN-DEPENDENT DISORDERS OF THE UNITED ANDROGENIC, ANDROGENIC, SEA, ANDROGEN, ALBACEA. LOCAL TREATMENT OF SCAMOUS CELL CARCINOMA |