| abstract |
REFERS TO A MULTIPLE LINK COMPOUND (L) p (X) q, WHERE L IS A LINK; X IS A LINK; p ES 2-10; q IS 1-20; EACH LINKING UNDERSTAND A LINKING DOMAIN CAPABLE OF LINKING TO A SODIUM CHANNEL; EACH LINKING INHIBITS THE GENERATION AND CONDUCT OF ACTION POTENTIALS; EACH LEAGUE INCLUDES AN AR-W GROUP; Ar IS ARYL, HETEROCYCLE, HETEROARYL; W ES - [CR1R2] rCO-, COO [CR1R2] r-, -OCO [CR1R2] r, AMONG OTHERS; r IS 0-10; R1 AND R2 ARE H, ALKYL, NRaRb, AMONG OTHERS; Ra AND Rb ARE ALKYL; EACH LINK X IS 1) -NR3-Z-NR4-; Z IS ALKYLENE, (ALKYLENE-O) w-ALKYLENE, ALKYLENE, AMONG OTHERS; w IS 1-10; R3 AND R4 ARE H, ALKYL, ARALKYL, LINKING, X-LINKING OR R3 AND R4 FORM, TOGETHER WITH Z, A HETERO CYCLE WITH AN N AND OPTIONALLY WITH 1-4 O, S, SO2, SO, NR` '; R '' IS A LINK, H, RENT; 2) -Ya-Z'-Yb-; Z 'IS A HETEROCYCLE, ARYL, HETEROARYL, A RING WITH 2 N, -NR-; R IS RENT; Ya AND Yb ARE A LINK, ALKYLENE, (ALKYLENE-O) w-, ALKYLENE, -CO- (CH2) n-NR-; n IS 1-10. Ar-W IS PREFERRED 2,6-DIMETHYLPHENYL-NH-CO-CH2-, -O-TOLYL-NH-CO-CH (CH2CH3), 4 - [- CO-O- (CH2) 2-N (CH2CH3) 2] -PHENYL, 4-AMINOPHENIL-CO-, AMONG OTHERS. IT ALSO REFERS TO A PROCEDURE FOR PREPARATION. THE COMPOUND (L) p (X) q MAY BE USEFUL AS A LOCAL ANESTHETIC |