| abstract |
REFERS TO DIHYDROXYHEXANOIC ACIDS OF FORMULA I, 4 (R) -CARBAMOIL-1 (S) - (3-CHLORO-BENZYL) -2 (S), 7-DIHYDROXY-7-METHYL-OCYL] -AMIDE OF QUINOXALINE ACID -2-CARBOXYL, (1S) -BENZYL-4 (R) -CARBAMOYL-2 (S), 7-DIHYDROXY-7-METHYL-OCYL) -AMIDE OF 7,8-DIFLUOROQUINOLINE-3-CARBOXYL ACID, AMONG OTHERS. COMPOUND I IS A POTENT AND SELECTIVE INHIBITOR OF THE BINDING OF CHEMOTACTIC PEPTIDE (CHEMOKINES) MIP-1O TO ITS RECEPTOR CCR1 IN INFLAMMATORY AND IMMUNOMODULATING CELLS SUCH AS LEUKOCYTES AND LYMPHOCYTES INFLUENCES AND INFLUENZA INFLUENCES, AND TRADED TO BE INFLAMMED LAYFUNCY INFLAMMED LAW CHRONIC, ALLERGIC CONDITIONS, INFECTION ASSOCIATED WITH INFLAMMATION, VIRAL DISEASES, TISSUE TRANSPLANT REJECTION, ATHEROSCLEROSIS, RESTENOSIS, HIV INFECTION, GRANULOMATOSOUS DISEASES |