| abstract |
REFERS TO COMPOUNDS I, X IS O, NRd or S; n, u AND l ARE 0-2; m ES 1, E and ES 1-3; m ES 2 E and ES 0; Rc IS H, C1-C6 ALKYL, - (CH2) n1-R4; n1 IS 1-6; Rd IS H, C1-C6 ALKYL, CN, ORa, AMONG OTHERS; R4 IS -ORa, SRa, -CN, -N (-Ra) (-Rb), -C (= O) -N (-Ra) (-Rb), AMONG OTHERS; Rc` IS H, C1-C6 ALKYL, (CH2) nORa, ONLY ONE Rc or Rc 'IS NOT H; EACH Ra AND Rb IS H, C1-C6 ALKYL, PHENYL, BENZYL, ALLYL; WHEN R4 IS -N - (- Rb) -C (= O) -ORa; Ra IS NOT H; OR WHEN Ra AND Rb JOIN THE N AND FORM A RING OF 4 TO 7 MEMBERS; EACH R1 AND R2 IS H, C1-C6 ALKYL, CF3, C2F5, AMONG OTHERS; Ra IS NOT H IN -S (= O) -Ra, -S (= O) (= O) -Ra, -N (-Rb) -C (= O) -ORa; OR WHEN R1 AND R2 ARE A GROUP b; n 'IS 1 or 2; EACH R3 IS H, C1-C6 ALKYL, CF3, AMONG OTHERS; Ar1 IS HETEROARYL OF FORMULA c, Q IS N or CH; Ar2 IS HETEROARYL OF FORMULA d; Z IS A GROUP e; m1 IS 0-1; m2 IS 1-2; n3 IS 0-4; EACH Re AND Rf ARE H, C1-C6 ALKYL, PHENYL, BENZYL, ALLYL, or Re AND Rf FORM A CARBONYL IN GROUP f; n5 IS 1-2; R5 IS H, C1-C6 ALKYL, (CH2) n1-R4, AMONG OTHERS, R6 IS H, C1-C6 ALKYL, AMONG OTHERS; WHEN X3 IS H, O, NRd, or S; R6 IS HETEROARYL, HETEROCYCLOALKYL, WHEN n3 IS 0-4. COMPOUND I IS ANTAGONIST OF THE NEUROQUININ RECEPTOR (NK), OF PREFERENCE NK1 AND MAY BE USEFUL IN THE TREATMENT OF ASTHMA, ANXIETY, DEPRESSION, EMESIS, SKIN DISORDER, COUGH |