| abstract |
REFERS TO A COMPOUND OF FORMULA I, WHERE R1 IS C1-C6 ALKYL; R2 IS H, C1-C6 ALKYL, C1-C6 HALOALKYL or PHENYL; R3 IS H or HALOGEN; R4 AND R5 ARE H, C1-C6 ALKYL or C1-C6 HALOALKYL; n IS 1-3. PREFERRED COMPOUNDS ARE (2S, 3S) -3 - [(1R) - (6-METOXY-1-METHYL-1-TRIFLUOROMETHYL ISOCROMAN-7-IL] METHYLAMINO-2-PHENYLPIPERIDINE; (2S, 3S) -3 - [(3R ) - (6-METHOXY) -3-METHYL-3-TRIFLUOROMETHYL-1,3-DIHYDROBENZOFURAN-5-IL) METHYLAMINO-2-PHENYLPIPERIDINE, AMONG OTHERS. ALSO REFERS TO A COMPOUND OF FORMULA III, WHERE W IS H or Q (O =) C-; Q IS H, C1-C6 ALKYL, C1-C6 HALOALKYL. COMPOUND I IS AN ANTAGONIST TO SUBSTANCE P (TACHYCININ PEPTIDE) AND MAY BE USEFUL FOR THE TREATMENT OF CARDIOVASCULAR DISEASES, ALLERGIC DISORDERS, ANGIOGENESIS, GASTROINTESTINAL DISORDERS, INFLUENTIC EMERGENCY DISORDERS, CENTRAL EMERGENCY DISORDERS, INFLUENTIC EMERGENCY DISORDERS, CENTRAL EMISSION DISORDERS , MIGRANE, SEVERE ANXIETY DISORDERS, STRESS DISORDERS, SUNBURNS, HELICOBACTER PILORI DISORDERS, SEXUAL DYSFUNCTION |