| abstract |
REFERS TO A FORMULATION FOR THE CONTROLLED RELEASE OF A SELECTIVE SEROTONIN REABSORPTION INHIBITOR (SSRI), WHICH INCLUDES: 1) DEPOSIT-NUCLEUM, CONTAINING: AN SSRS, WHICH PREFERABLY IS "PARAMETHINE", AND [A POLYMERIC MATERIAL WHICH IT IS INFLATED AND A GELIFICABLE POLYMERIC MATERIAL or A POLYMERIC MATERIAL WITH INFLATION AND GELIFICATION PROPERTIES]; 2) SUPPORT-PLATFORM, CONTAINING AN ELASTIC SUPPORT, TO PARTIALLY COVER THE SURFACE OF THE DEPOSIT-NUCLEUM AND TO BE SLOWLY SOLUBLE AND / OR GELABLE IN AQUEOUS FLUIDS. FURTHER REFERS TO A COMPLEX OF REACTION (IN THE NUCLEUS) BETWEEN THE CALCIUM POLYCARBOFIL (INFLATABLE POLYMER CONTAINING: 80% CARBOXY FUNCTIONALITY AND FROM 0.05% TO 1.5% OF RETICULATING AGENT) AND WATER, IN THE PRESENCE OF SSRI. THIS CONTROLLED RELEASE REDUCES NAUSE, A FREQUENT SIDE EFFECT ON IMMEDIATE RELEASE OF THE SSRI. USED IN THE TREATMENT OR PROPHYLAXIS OF DEPRESSION, AMONG OTHERS |