| abstract |
WHICH INCLUDES: A) MIXING A SELECTED ALIPHATIC POLYMER AMONG THE GROUP CONSISTING OF POLYCHAPROLACTONE, GLYCOLIC ACID (POLY), POLY (HYDROXYBUTYRATE), POLY (HYDROXIVALERATE), ADIPATE LACTIC / GLYCOLIC, MICROENCAPSULATED HYDROXYBUTYRATE / HYDROXYVALERATE COPOLYMERS WITH A SUPERCRITICAL FLUID WHICH MAY BE N20 SUPERCRITICAL OR C02 SUPERCRITICAL WITH CAPACITIES UNUERABLE ANUERABLE PUERTAIN UNULEEUER, ANTI-PUERTAIN UNEURABLE, IT INCLUDES AN UNCOATED VIRUS, PRODUCING THE MIXTURE AT PRESSURE AND TEMPERATURE SUITABLE TO MAINTAIN THE FLUID IN A SUPERCRITICAL STATE AND AT A TEMPERATURE ENOUGH TO LIQUIDATE THE POLYMER; B) OVERCOOLING THE LIQUEFIED POLYMER AT A TEMPERATURE LESS THAN THOSE IN WHICH THE THERMOLABIL NUCLEO MATERIAL IS ADVERSELY AFFECTED; C) MIX THE THERMOLABIL MATERIAL WITH THE OVERCOOLED LIQUEFIED POLYMER WHILE MAINTAINING TEMPERATURE AND PRESSURE ARE MAINTAINED TO MAINTAIN THE SUPERCRITICAL FLUID IN A SUPERCRITICAL STATE; AND D) RELEASE THE PRESSURE TO SOLIDIFY THE POLYMER AROUND THERMOLABIL MATERIAL IN ORDER TO FORM MICROCAPSULES |