| abstract |
REFERS TO COMPOUNDS OF FORMULA I, WHERE X IS A LINK, -O-, ALKYLENE C1-C4, OR ALKYLENE C1-C8 OPTIONALLY REPLACED BY O-ALKYLENE C1-C3, -O-CH2-CH2-O-, -O -CH2-CH2-NH-; R1 IS H, METHYL, ETHYL, PHENYL; R2 IS H, METHYL; R3 IS H, HALO, OH, METHYL, METOXY; R4, R5, and R6 ARE H, METHYL, ETHYL; R7 IS T-BUTYL, CYCLLOHEXYL, PHENYL SUBSTITUTED FOR R9 AND R10, GROUP a; R8 IS H, C1-C4 ALKYL; Z IS O, NH, SULFUR; R9 AND R10 ARE H, METHYL, HALO, METOXI. A PREFERRED COMPOUND IS (-) - (1R, 2 "S) -2- (2" -BENCILOXI) PROPIL-4`-HIDROXI-5,9,9-TRIMETIL-6,7-BENZOMORFANO, AMONG OTHERS. IT ALSO REFERS TO A PROCEDURE FOR PREPARATION. COMPOUND I IS A POTENTIAL DEPENDENT SODIUM CHANNEL BLOCKER, USING 0.001% -20% BY WEIGHT AND MAY BE USEFUL FOR THE THERAPEUTIC TREATMENT OF BRAIN ISCHEMIA, NEURODEGENIAL DISEASES, EPILEPTICOA, HILIPEGIUM AND BRAIN EDEMA |