| abstract |
REFERS TO 2- (3H) -OXAZOLONE OF FORMULA I; R1 IS RENT OR AN AMINO GROUP; R2 IS A CHRONICLE, OPHALLY SUBSTITUTED PHENYL; R3 IS A H, RENT. IT ALSO REFERS TO A COMPOUND OF FORMULA II, WHERE R1 IS CH3, NH2; R3 IS H, CH3; R4 IS H, CH3, Cl, F; R5 IS H, F, CH3, Cl; R6 IS CH3CH2, CH3O, H, Br, F, CF3; R7 IS H, F; R8 IS H. ALSO REFERS TO A PROCEDURE FOR PREPARATION. COMPOUND I IS A CYCLOOXYGENASE 2 (COX-2) INHIBITOR AND MAY BE USEFUL TO TREAT PAIN, FEVER, OR INFLAMMATION, TO INHIBIT PROSTANOID-INDUCED MUSCLE CONTRACTION, COLORECTAL CANCER PREVENTION |