| abstract |
IT REFERS TO A COMPOUND OF FORMULA I, A IS SO2Ar, COAr, CONHAr, PORAr; Ar IS AN AROMATIC OR HETEROAROMATIC MONOCYCLE OR BICYCLE; R1 IS ALKYL or H; R2, R3 AND R4 ARE H, ALKYL, ARYL, HETEROARYL, ARYLALKYL, ALCOXYALKYL, OR R2 AND R3, R1 AND R2, R3 AND R4 FORM A HETEROCICLE OR HETEROCICLOALKYL; X IS A LINK, C1-C6 ALKYL, CO, O, N, S, SO, SO2; AND IT IS A LINK, C1-C6 ALKYL, CO, CO2, CONH2, O, N, S, SO, SO2; Z IS H, COR4, COOR4, CONHR4, R4, CSR4, CSNHR4 AND SO2R4. COMPOUND I IS A METALOPROTEASE INHIBITOR AND MAY BE USEFUL FOR TREATING A DISEASE SUCH AS ARTHRITIS, CANCER, CARDIOVASCULAR DISORDERS, EYE DISORDERS, INFLAMMATION, AND GUM DISEASE |