| abstract |
THEY REFER TO COMPOUNDS OF FORMULA (I), WHERE: Ar IS ALKYL, HETEROALKYL, ARYL or HETEROARYL; "W" IS ONE OR MORE LOWER RENT GROUPS, OR IS A BRIDGE (ALKYLENE, ARYLENE OR HETEROARYLENE) OR DOES NOT EXIST; "Y" IS H, OH, SR3, SOR4, SO2R5, ALCOXIL or NR6R7; "Z" IS A SPIRAL SHAPED GROUP, FORMING A RING OF 5 TO 7 MEMBERS WITH THE CARBON TO WHICH IT IS ATTACHED, PRESENTING "Z" ONE OR MORE HETEROATOMES O or S; R1 IS H; R2 IS H, ALKYL or ACIL; R3 IS H, ALKYL, ARYL, HETEROARYL, AMONG OTHERS; R4 IS ALKYL, ARYL, or HETEROARYL; R6 AND R7 ARE H, ALKYL, HETEROALKYL, HETEROARYL, ARYL, OR3, AMONG OTHERS; R8 IS ALKYL, ARYL, HETEROARYL OR HETEROALKYL; R9 IS H, ALCOXI, ARYLOX, AMONG OTHERS; n IS 1; 2 or 3. THE COMPOUNDS OF FORMULA (I) ACT AS INHIBITORS OF THE METALLOPROTEASY ENZYMES OF THE MATRIX, BEING USEFUL IN THE TREATMENT OF RHEUMATOID ARTHRITIS, OSTEOARTHRIAL DISEASES, CARDIOVAL DISEASES, AND CARDIOVAL DISEASES |