| abstract |
THE PRESENT INVENTION REFERS TO HETEROARIL- AND PHENYLSULFAMOIL SUBSTITUTED COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH COMPOUNDS AND THE USE OF SUCH COMPOUNDS AS AGONISTS OF THE ACTIVATOR RECEIVER OF THE PEROXISOM PROLIFERATOR (PPAR). PPAR ALFA ACTIVATORS, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH COMPOUNDS AND THE USE OF SUCH COMPOUNDS ARE USEFUL TO ELEVATE CERTAIN LEVELS OF LIPIDOS IN PLASMA, INCLUDING CHOLESTEROL-LIPOPROTEIN HIGH DENSITY AND TO REDUCE DIFFERENT COLORS IN LDLES TRIGLICERIDS AND THEREFORE TO TREAT DISEASES THAT START WITH LOW LEVELS OF CHOLESTEROL HDL AND / OR HIGH LEVELS OF CHOLESTEROL-LDL AND TRIGLICERIDES SUCH AS ATEROSCLEROSIS AND CARDIOVASCULAR DISEASES IN MUMPHOSOS SERIES. THE COMPOUNDS ARE ALSO USEFUL FOR THE TREATMENT OF THE NEGATIVE ENERGY BALANCE (NEB) AND ASSOCIATED DISEASES IN RUMINANTS. |