| abstract |
THE INVENTION REFERS TO A FORMULA COMPOUND (I) AN N-OXIDE, A PHARMACEUTICALLY ACCEPTABLE ADDITION SALT, A QUARTERLY AMINE, A POLYMORPHIC FORM OR A STEREOCHEMICALLY ISOMERIC FORM OF THE SAME, WHERE R1 CLOCK CROQUOIL -7, C1-6 RENT-C1-6 RENT, DI (RENT 1-6) AMINO C1-6 RENT, ARYL OR HETEROARILE; EACH R2 REPRESENTS INDEPENDENTLY HALO, C1-6 RENT, C1-6 RENT, C1-6 RENT, POLIHALO-RENT1-6 POLY-RENTROXYL C1-6, Cyan, AMINOCARBONYL, AMINO, MONO- OR DI (RENT) NITRO, ARYL OR ARYLOXYL; R3 REPRESENTS HYDROGEN, CYAN, C1-6 RENT OPTIONALLY REPLACED, C (= O) -O-R5, C (= O) -NR6AR Ò B, C (= S) -NR6A R6B, S (= O) 2-NR6AR6B OC (= O) -R7; R4 REPRESENTS HYDROGEN OR RENT C1-6; N ES 1, 2, 3, 4 O 5; Z REPRESENTS A CYCLE CANCELLATION SYSTEM. THE INVENTION ALSO REFERS TO PROCESSES TO PREPARE THE FORMULA COMPOUNDS (I), ITS USE AS AN ANTIGONIST OF THE CCR2 RECEIVER AND THE PHARMACEUTICAL COMPOSITIONS THAT UNDERSTAND IT. |