| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c4df108cb4c2f6009ddbfe8c1e3093cd |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-132
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-661
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-047 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-047
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-132 |
| filingDate |
2002-11-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_81bbea0a51ddb05b3e3bd120f9844e5c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5043b2847570d45d09d933306ec0fcbe
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e627374ece50c38ef8f60fa7fb72c6ed
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b9e746c6133bd2ebcdccc492fe255389
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4c3a5c0c7197a4063707ff7d2e8bf0d7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0b3035fc1c8b7ca94b83700b2922674c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_47d728459b487bdb465dfde07ef5de43
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5d393bfffbeaaa280361af00f868b14c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_15abb7be9d7e1078b3c2ddce72e5b9a6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c53a6f618632378599fe498abffaa9fb |
| publicationDate |
2006-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
OA-13138-A |
| titleOfInvention |
Immunoregulator compounds. |
| abstract |
The invention relates to sphingosine derivative compounds, like D-erythro-sphingosine 1-phosphate (S1 P), to be used as immunomodulators in a microbicidal treatment of infections derived from bacteria and specifically Mycobacterium tuberculosis. Such compounds are characterised in that they stimulate macrophagic Phospholipase D (PLD) (FIG. 1). The invention further relates to pharmaceutical compositions containing sphingosine derivative compounds and diagnostic methods for the preparation thereof. Further objects of the invention are methods of inducing or restoring the microbicidal activity in vitro of macrophages for monitoring the efficiency of phagocytosis and degradation processes performed by the same and assay methods suitable to evaluate therapeutic effectiveness of candidate microbicides. |
| priorityDate |
2001-11-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |