| abstract |
The present invention relates to compounds of formula (1) and pharmaceutically acceptable salts and solvates thereof wherein R<1>, R<2>, R<3>, R<4>, R<5>, R<6>, R<7>, R<8>, R<9>, and Z are as defined herein. The invention also relates to pharmaceutical compositions comprising compounds of formula (1) and to methods of inhibiting abnormal cell growth, including cancer, in a mammal by administering compounds of formula (1) to the mammal. The invention also relates to intermediates and methods useful in synthesizing compounds of formula (1). |