| abstract |
Novel S-nitrosothiols derivatives of penicillamine or glutathione, which correspond to following general formula(I) <CHEM> in which: A and B are phenyl groups or together form the rest -CH2-Q-CH2- constituting a ring of six units in which Q represents an atom of oxygen, of sulfur, or a group N-R<3>, in which R<3> is hydrogen or an alkyl group C1-C4; R<1> is an acyl rest, which may be an aliphatic acyl group C1-C5 or a rest of glutamic acid bound via its non amino acid carboxyl; R<2> is a hydroxyl group or a glycine rest bound via a peptide bond; with the proviso that if R<1> is an aliphatic acyl rest then R<2> is a hydroxyl group, and if R<1> is a rest of glutamic acid then R<2> is a glycine rest. The novel compounds have vasodilating activity arid inhibit the aggregation of the platelets, which make them useful for the treatment of dysfunctions of the circulatory system, specially at cardiovascular level. |