abstract |
The present invention relates to analogues of Sialyl Lewis<x> that inhibit cellular adhesion between a selectin receptor and cells that express sialyl Le<x> on their surfaces, as well as methods and compositions using the same, intermediates and methods for the preparation of the cellular adhesion inhibitor compounds and their intermediates. A contemplated intermediate or inhibitor compound has the 2-N-acetyl moiety of the GlcNAc substituted with YR<1> wherein Y is C(O), SO2, HNC(O) or SC(O) and R<1> is aryl, substituted aryl, or phenyl C1-C3 alkylene moieties. |