http://rdf.ncbi.nlm.nih.gov/pubchem/patent/NZ-761931-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c4423185f79003e8f9b981e29323454a |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C59-245 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 |
| filingDate | 2010-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_17010087617e259300a443272f1004f1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_92c0fa0a955fcc97efbfbc1a1b32d7bf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_160d4881d64c4df08137d1cbe216ad83 |
| publicationDate | 2021-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | NZ-761931-A |
| titleOfInvention | Malate salt of n-(4-{ [6,7-bis(methyloxy)quinolin-4-yl] oxy} phenyl)-n’-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, and crystalline forms thereof for the treatment of cancer |
| abstract | Disclosed is the use of N-(4-{ [6,7-bis(methyloxy)quinolin-4-yl]oxy} phenyl)-N’-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide, malate salt (cabozantinib malate) in the manufacture of a medicament for the treatment of a cancer selected from kidney cancer and liver cancer, wherein said salt is in crystalline Form N-1 or crystalline Form N-2. Form N-1 can be characterised by a powder x-ray diffraction pattern (CuKα λ=1.5418Å) comprising 2θ (±0.2 °2θ) values of: 6.4, 9.0, 12.0, 12.8, 13.5, 16.9, 18.2, 19.4, 21.5, 22.8, 24.0, 25.1 and 27.6. Form N-2 can be characterised by a powder x-ray diffraction pattern (CuKα λ=1.5418Å) comprising 2θ values (±0.2 °2θ) 6.4, 9.1, 12.0, 12.8, 13.7, 17.1, 18.2. 20.9, 21.9, 22.6 and 23.7. |
| priorityDate | 2009-01-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
| Predicate | Subject |
|---|---|
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID449323808 http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID25102846 |
Total number of triples: 18.