| abstract |
The controlling the glycoprotein structures is very important in the field of development of recombinant glycoprotein products for medicines and development of mass production technology. The present invention relates to a method for controlling a glycosylation pattern of a recombinant glycoprotein, comprising culturing a cell comprising polynucleotide encoding a recombinant glycoprotein in a culture medium comprising insulin. The method for controlling the glycosylation of the recombinant glycoprotein according to the present invention can control an activity, folding, secretion, stability, a half-life in plasma, and an immune response of the recombinant glycoprotein. |