| abstract |
Disclosed is combination of benzodioxane compounds of formula (I) and an additional agent active selected from the group consisting of statins, HMG-CoA reductase inhibitors, cholesterol ester transfer protein (CETP) inhibitors or antagonists, fibrates, niacin derivatives, LpPLA2-inhibitors, antiplatelets and anticoagulants. In a preferred embodiment, the active agent is the statin simvastatin. The combination is useful inhibiting leukotriene production and treating cardiovascular disease. Examples of a compound of formula (I) are: 1-[4-(2,3-dihydro-1,4-benzodioxin-2-yl)benzyl]pyrrolidine N-[4-(2,3-dihydro-1,4-benzodioxin-2-yl)benzyl]cyclopentanamine (1-{ 4-[(2S)-2,3-dihydro-1,4-benzodioxin-2-yl]benzyl} piperidin-4-yl)methanol |