| abstract |
Provided are substituted phenylazole derivative compounds of the general formulae (I), (II) and (III), wherein the variables are as defined in the specification. Examples of the compounds include 4-{ 4-[(1R)-1-{ [6-(Cyclopropylcarbonyl)pyridin-3-yl]oxy} ethyl]-2H-1,2,3-triazol-2-yl} -N-[(1R,2R)-2,3-dihydroxy-1-methylpropyl]-2-fluorobenzamide and 4-{ 5-[(1R)-1-{ [6-(Cyclopropylcarbonyl)pyridin-3-yl]oxy} ethyl]-1,2,4-oxadiazol-3-yl} -2-fluoro-N-[(1R)-2-hydroxy-1-methylethyl]benzamide. The compounds have hypoglycemic activity and protect beta-islet cells and/or the pancreas. The compounds may be useful in the treatment of diabetes. |