| abstract |
Disclosed is the use of p75 receptor antagonist compounds of formula (I) for the preparation of a medicament for use in the treatment and/or prevention of overactive bladder. Examples of a compound of formula (I) are: 1-[4-(4-chloro-3-trifluoromethyl-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-2-[8-(5-fluoro-pyrimidin-2-yl)-3,8-diaza-bicyclo[3,2,1]oct-3-yl]-ethanone 6-{ (3S,5R)-3,5-Dimethyl-4-[2-oxo-2-(2-phenyl-2,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl)ethyl]piperazin-1-yl} nicotinic acid hydrochloride 6-{ (3S,5R)-4-[2-(4-benzofuran-7-yl-3,6-dihydro-2H-pyridin-1-yl)-2-oxoethyl]-3,5-dimethylpiperazin-1-yl} nicotinic acid 1-(2-phenyl-2,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl)-2-(8-pyridin-3-yl-3,8-diazabicyclo[3,2,1]oct-3-yl)ethanone |