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publicationDate 2015-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber NZ-626199-A
titleOfInvention Thieno- and furo - pyrimidines and pyridines, useful as potassium channel inhibitors
abstract Disclosed herein are thieno and furo pyridine and pyrimidine compounds of formula (I) wherein R3 is N(RaRb)J where Ra and Rb form a ring with the nitrogen to which they are attached and the remainder of the substituents are as are defined herein. The compounds are potassium channel inhibitors intended for use in treatment of diseases or conditions that are mediated by KI3.1 and/or Kir3.4 or any heteromultimers thereof, or that require inhibition of Kir3.1 and/or Kir3.4 or any heteromultimers thereof such as cardiovascular diseases. Also disclosed are pharmaceutical compositions comprising the compounds of formula (I).
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Total number of triples: 45.