| abstract |
A pharmaceutical dosage form for treatment of cardiovascular disorders and suitable for once daily administration comprising a fixed dose combination of: (a) metoprolol or a pharmaceutically acceptable salt thereof in extended release form, (b) Clopidogrel or a pharmaceutically acceptable salt thereof, and (c) one or more rate controlling excipients. The dosage form exhibits a dissolution profile such that less than 6% of metoprolol or a pharmaceutically acceptable salt thereof is released within 1 hour, when the release rate is measured in USP Type 2 Dissolution apparatus in paddle type at 50 rpm using 500 ml of pH 6.8 phosphate buffer at 37°C ± 0.5°C as dissolution medium. |